Asked by js77 on Mon 8 Feb 2010 - 2:38 am UTC:

Tetrabenazine (Xenazine) is a drug that reduces catecholamine blood plasma
levels, two of which are epinephrine and norepinephrine. I want to know
whether or not tetrabenazine reduces just epinephrine blood plasma levels,
just norepinephrine blood plasma levels, or both, and by what percentage in
the study found.

If a study on blood plasma levels can't be found, I'll alternatively accept
a study showing whether or not tetrabenazine reduces norepinephrine in just
sympathetic peripheral nerve endings, epinephrine in just the adrenal
glands, or both, and by what percentage in the study found, so long as the
study tested both the sympathetic peripheral nerve endings for
norepinephrine levels and the adrenal glands for epinephrine levels.

Here is an example of what I'm looking for:
http://content.onlinejacc.org/cgi/content/abstract/14/3/624 which shows a
decrease in norepinephrine levels after administration, but no decrease in
epinephrine levels. The percentage can be calculated from the info given.

I will also accept two different articles, if both of the articles combined
answers the question -- ex: one tests for blood plasma levels of
epinephrine and the other tests for levels of norepinephrine.

Possibly helpful info:
adrenaline is the same as epinephrine
noradrenaline is the same as norepinephrine