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ANSWERED on Sat 28 Jan 2012 - 1:46 pm UTC by umiat

Question: photoluminescence - Ultraviolet Blood Irradiation (UBI) therapy

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Tue 24 Jan 2012 - 2:44 pm UTC

Question

disquisitive
Customer

1) I seek articles for and against UBI therapy 2) articles citing possible harm from UBI therapy.

From: http://www.mnwelldir.org/docs/uv_light/uv_light3.htm

"Photoluminescence Therapy for the following conditions:

Immune deficiency problems
Viral Infections (hepatitis, respiratory, etc.)
Pneumonia
Non-healing wounds and wound infections
Emphysema
Inflammatory Processes: fibrositis (inflammation of, mainly, the muscle sheath), bursitis, iritis (inflammation of the iris), pancreatitis, etc
Autoimmune diseases: rheumatoid arthritis, AIDS, etc.
Osteomyelitis (bacterial infection of the bone marrow)
Septicemia (virulent infection of the blood)
Cancer (experimental at present)
Peripheral vascular disease
Most vascular disease
Thrombophlebitis (inflammation of a blood vessel that results in blood clots)"

 
 

Wed 25 Jan 2012 - 7:10 am UTC

Question clarification

disquisitive
Customer

Ultraviolet Blood Irradiation (UBI) therapy is a medical process of photo-oxidation using the healing power of light. It has also been written about under other titles:

Hemo-irradiation
Photopheresis
Photochemotherapy
Photobiological therapy
and photodynamic therapy.

 

Wed 25 Jan 2012 - 10:24 am UTC

Comment

myoarin
User

And a German racing ice skater has been accused of using it as a form of doping, apparently because it is thought that UV-irradiation improves oxygenation.

 

Wed 25 Jan 2012 - 6:06 pm UTC

Comment

disquisitive
Customer

myoarin thank you for the comment about this story: http://www.cyclingnews.com/news/black-light-blood-treatments-in-germany

 

Wed 25 Jan 2012 - 7:20 pm UTC

Uclue Researcher Request for clarification

David Sarokin
Researcher

Please have a look at these articles and let me know if they are the sort of resources you're seeking:

http://onlinelibrary.wiley.com/doi/10.3322/canjclin.20.4.248/pdf
Ultraviolet Blood Irradiation Intravenous Treatment


http://en.wikipedia.org/wiki/Blood_irradiation_therapy
Blood irradiation therapy


Although you've probably seen the Wikipedia article already, it struck me as a pretty good overview article on this topic. It also explains why many of the articles on UBI are in Chinese and Russian, and do not necessarily have English translations available.

David

 

Wed 25 Jan 2012 - 8:29 pm UTC

Question clarification

disquisitive
Customer

Yes these are the resources I am seeking. Unfortunate to have more information available in Chinese and Russian.

From the Wikipedia article you have cited: "Laser blood irradiation therapy was government-certified in Germany in 2005. In the following two years, this method was established in more than 300 centers in Germany, Austria, Switzerland, Italy and Australia". Articles are also probably available in German.

 

Thu 26 Jan 2012 - 1:11 am UTC

Comment

myoarin
User

There are quite a few hits found by googling with:   UV Blutbestrahlung

Here are two lists of articles.  I haven't compared them for duplicates:
http://www.antioxidant-research.eu/ausgewaehltepublikationen.php
http://finden.nationallizenzen.de/Record/ZDB-1-SOJ@199316643

This is the first link Google shows (the one most often clicked on, I believe, maybe because the doctor "captured" the website name):
http://www.uvblutbestrahlung.de/

There are, indeed, many German language medical doctors and alternative medical practitioners (Heilpraktiker) who offer blood irridiation .
"Centers" would be exaggerating their significance.    

As the Wikipedia article explains:

"Die ultraviolette Blutbestrahlung (UVB, Synonym fotobiologische Therapie, UV-aktivierte Eigenbluttherapie, UVE) ist eine alternativmedizinische Behandlungsmethode und Unterform der Eigenbluttherapie. Eine wissenschaftlich belegte Wirksamkeit hat dieses Behandlungsverfahren nicht."
Briefly:  the therapy is an *alternative medicine* treatment.  It does not have scientifically demonstrated efficacy.

Also:
"Der deutsche Gemeinsame Bundesausschuss der Ärzte und Krankenkassen untersuchte das Verfahren und kam 2001 zu dem Fazit, dass „Nutzen, Notwendigkeit und Wirtschaftlichkeit nicht belegt“ sind. Daher bezahlen die Kassen es nicht; auch die meisten Privatversicherer lehnen die Kostenübernahme ab."
The German combined committee of doctors and health insurers researched the treatment and in 2001 agreed that its benefits, necessity and cost effectiveness are not proven.  Therefore, the compulsory insurers and most private insurers refuse to pay for the treatment.
 
http://de.wikipedia.org/wiki/UV-bestrahltes_Blut
(The article was last amended in July 2010 and has no "discussion".)

In Germany, alternative (complementary) medicine is perhaps more popular than elsewhere.

 

Thu 26 Jan 2012 - 5:12 pm UTC

Comment

disquisitive
Customer

Thank you myoarin. Your contributions and German translations are welcomed.

 

Fri 27 Jan 2012 - 12:37 am UTC

Uclue Researcher Request for clarification

JD Umiat
Researcher

Hello, disquisitive,

 Can you please tell me if the procedures outlined in these two articles is similar (or an updated version) of the UBI therapy you are interested in?

Extracorporeal photoimmune therapy: A therapeutic alternative treatment of cutaneous Tcell lymphoma and immunological diseases
http://www.cancer-therapy.org/CT/v2/A/PDF22.%20Martino%20et%20al,%20177-185.pdf

Safety and Efficacy of Extracorporeal Photoimmune Therapy With UVADEX for the Treatment of Rheumatoid Arthritis (RA-1)
http://clinicaltrials.gov/ct2/show/NCT00221000

The Cleveland Clinic mentions that photopheresis might be offered as a therapy for graft versus host disease.
http://my.clevelandclinic.org/services/photopheresis/hic_photopheresis.aspx

Photopheresis or extracorporeal photoimmune therapy is a procedure that might be recommended by your doctor to prevent or to treat graft versus host disease (GvHD). This procedure offers another way to try to suppress the donor lymphocytes (type of white blood cells) that stimulate immune reactions and aid in the development of GvHD.

Read more.....

What are the side effects?

A few patients might experience a slight drop in blood pressure during the procedure. This is easily corrected by receiving intravenous fluids.

Another possible side effect is fever about 6 to 8 hours after the procedure. Please tell your doctor if you have a temperature over 100° F. Your doctor might recommend you take additional medicines such as acetaminophen (Tylenol®).

Precautions after treatment

You must avoid sunlight, even if it's indirect sunlight, for 24 hours after each procedure since you will be more sensitive to the sun. If you go outside, please apply sunscreen with at least SPF 15. Please wear UVA protective sunglasses in a "wraparound" style to protect the sides of your eyes. UVA sunglasses are available in many colors, including clear, at most drug stores for about $20. It is recommended that you wear these both inside and outside for 24 hours after each procedure.


 If these articles are of interest, I can possibly follow this route further. Unfortunately, the only hits I can find for your other search terms are simply from practitioner's offices with no real scientific information about the practice other than what you have already reviewed.

umiat

 

Fri 27 Jan 2012 - 2:03 am UTC

Uclue Researcher Request for clarification

JD Umiat
Researcher

The following article from Cancer.org also uses the terms photodymanic therapy, UV blood irradiation and photopheresis or extracorporeal photochemotherapy as similar processes.
 
"Photodynamic therapy is helpful in treating certain cancers or precancers of the skin, esophagus, and lungs, and is now being tested against other types of cancer. A special form of UV blood irradiation, called photopheresis or extracorporeal photochemotherapy, also inhibits T-cell lymphoma and may be helpful for other conditions."
http://www.cancer.org/Treatment/TreatmentsandSideEffects/ComplementaryandAlternativeMedicine/ManualHealingandPhysicalTouch/light-therapy

Let me know what you think.

umiat

 

Fri 27 Jan 2012 - 8:36 am UTC

Question clarification

disquisitive
Customer

Yes umiat these articles are of interest. Thank you. Can you repost the first link re: Extracorporeal photoimmune therapy as I was unable to open it?

I am interested in English language articles from professionals or mechanically translated from other languages supporting or cautioning against and condemning Ultraviolet Blood Irradiation (UBI) therapies relating to cancer.

 

Fri 27 Jan 2012 - 9:27 am UTC

Uclue Researcher Request for clarification

q21
Researcher

Just reposting umiat's link that didn't work (a previously missing slash included):
http://www.cancer-therapy.org/CT/v2/A/PDF/22.%20Martino%20et%20al,%20177-185.pdf

 

Fri 27 Jan 2012 - 12:54 pm UTC

Question clarification

disquisitive
Customer

Thank you q21 for reposting the link on extracorporeal photochemotherapy.

 

Fri 27 Jan 2012 - 1:05 pm UTC

Uclue Researcher Request for clarification

JD Umiat
Researcher

Okay. I will go ahead and pursue this direction as related to cancer and see what else I can find.

 

Sat 28 Jan 2012 - 1:46 pm UTC

Uclue Researcher Answer

JD Umiat
Researcher

Hello, disquisitve,

Here are some reputable references I have found using your suggested search terms. The two search phrases which brought up the most credible results were photodynamic therapy and Extracorporeal photoimmune therapy. I also used your other search terms and included reputable papers when I found them. I focused primarily on cancer according to your last clarification.

==

The National Cancer Institute provides an excellent overview of the use of photodynamic therapy as an alternative treatment for various types of cancer.

Photodynamic Therapy for Cancer
http://www.cancer.gov/cancertopics/factsheet/Therapy/photodynamic

==

Another comprehensive overview may be found in the following article from The Oncologist:

"Photodynamic Therapy in Oncology." Martijn Triesscheijna, Paul Baasa, Jan H. M. Schellensa, and Fiona A. Stewarta.
The Oncologist October 2006 vol. 11 no. 9 1034-1044
http://theoncologist.alphamedpress.org/content/11/9/1034.long

Abstract - "Photodynamic therapy (PDT) is increasingly being recognized as an attractive, alternative treatment modality for superficial cancer. Treatment consists of two relatively simple procedures: the administration of a photosensitive drug and illumination of the tumor to activate the drug. Efficacy is high for small superficial tumors and, except for temporary skin photosensitization, there are no long-term side effects if appropriate protocols are followed. Healing occurs with little or no scarring and the procedure can be repeated without cumulative toxicity. Considering the efficacy and lack of long-term toxicity of PDT, and the fact that the first treatment of cancer with PDT was done more than 100 years ago, one might expect that this treatment had already become an established therapy. However, PDT is currently offered in only a few selected centers, although it is slowly gaining acceptance as an alternative to conventional cancer therapies. Here, we show the developmental steps PDT underwent and summarize the current clinical applications. The data show that, when properly used, PDT is an effective alternative treatment option in oncology."

Read full article.....

==

 Here are some other select abstracts from PubMed using the search term "photodynamic therapy."

"Is photodynamic therapy a good alternative to surgery and radiotherapy in the treatment of head and neck cancer?"
Nyst HJ, Tan IB, Stewart FA, Balm AJ. Department of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands. Photodiagnosis Photodyn Ther. 2009 Mar;6(1):3-11. Epub 2009 May 5. http://www.ncbi.nlm.nih.gov/pubmed/19447366

Abstract: "The mainstay treatments for head and neck carcinomas are surgery, radiotherapy and chemotherapy. These treatment options may be associated with considerable complications. Radical radiotherapy and chemotherapy can generally be employed only once, which presents difficulties in cases of recurrent disease or second primaries within the irradiated field. Salvage surgery at the same site is often difficult, due to progressive tissue loss. In this respect photodynamic therapy (PDT) seems to be a good alternative treatment option for small, localized tumors; with a good outcome and with excellent functional and cosmetic results. Selected patients with advanced cancer of the head and neck, who have exhausted other treatment options, can also achieve improvement in quality of life with PDT. The advantages of PDT compared with surgery or radiotherapy are reduced long-term morbidity and the fact that PDT does not compromise future treatment options for recurrent, residual or second primary disease."

==

"Clinical outcomes of photodynamic therapy for head-and-neck cancer." Lou PJ, Jones L, Hopper C. National Medical Laser Centre, Department of Surgery, University College London, London, United Kingdom. Technol Cancer Res Treat. 2003 Aug;2(4):311-7. http://www.ncbi.nlm.nih.gov/pubmed/12892513

==

"Photodynamic therapy of head and neck tumors and non-tumor like disorders." Gerber-Leszczyszyn H, Zió?kowski P, Marszalik P. Department of Maxillo-Facial Surgery, Medical University Katedra i Klinika Chirurgii Szczekowo-Twarzowej AM we Wroclawiu. Otolaryngol Pol. 2004;58(2):339-43. http://www.ncbi.nlm.nih.gov/pubmed/15307481

"It has to be stressed that PDT is still less effective in the treatment of more advanced cases of head and neck cancer. As the method of treatment which improves the quality of life, its usefulness can be considered as well as palliative treatment of non-operative cases. 

** Although the method is not free of several side effects, such skin phototoxicity, burning, slight pain and edema in the irradiated location. All these side effects are transient and usually they disappear within 24 hours. **

The photodynamic treatment always results in excellent cosmetic effects without scarring or marring which are usually encountered after routine surgical operation."

==

"Photodynamic therapy of multiple nonmelanoma skin cancers with verteporfin and red light-emitting diodes: two-year results evaluating tumor response and cosmetic outcomes." Lui H, Hobbs L, Tope WD, Lee PK, Elmets C, Provost N, Chan A, Neyndorff H, Su XY, Jain H, Hamzavi I, McLean D, Bissonnette R. Division of Dermatology, University of British Columbia and Vancouver General Hospital, Vancouver, Canada. Arch Dermatol. 2004 Jan;140(1):26-32.
http://www.ncbi.nlm.nih.gov/pubmed/14732656

==

"Photodynamic therapy: applications in bladder cancer and other malignancies." Chang SC, Bown SG. Department of Urology, Tzu-Chi General Hospital, Hualien, Taiwan, ROC.
http://www.ncbi.nlm.nih.gov/pubmed/9409116

==

PUBMED results utilizing the search "photodynamic therapy" can be found here:
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=link&linkname=pubmed_pubmed&uid=12892513



ADDITIONAL
===========

"Perspectives on the Role of Photodynamic Therapy in the Treatment of Pancreatic Cancer." International Journal of Photoenergy. http://www.hindawi.com/journals/ijp/2012/637429/

 "PDT has many advantages, including its selective effect on malignant cancer cells of the pancreas versus normal tissue [18]. The precise reason for this phenomenon is still unclear, but it has been assumed to be related to an immunologic reaction [86]. Another advantage is that PDT does not lead to the accumulation of toxicity in patients [7, 87]. Furthermore, the combination of PDT with chemotherapy and other treatments can lead to significant additive benefits [22]. However, PDT also has some disadvantages. Side effects such as gastrointestinal bleeding and duodenal obstruction [78] have been noted. In addition, large tumor masses prevent PDT from penetrating the full depth of the cancerous tissue and thus diminish its efficiency [88]."

==

"Photodynamic therapy and Green Laser blood Therapy," By Zahra Al Timimi, M.S. Jaafar, Mohd Zubir Mat Jafri
Universiti Sains Malaysia, Penang, Malaysia
http://www.isla-laser.org/wp-content/uploads/5-Photodynamic-therapy-and-Green-Laser-blood-Therapy.pdf

==

"Treatment of graft-versus-host-disease with extracorporeal photochemotherapy (ECP, photopheresis)." Robert Knobler and the Vienna GVHD-ECP Team. Department of Dermatology, Division of Special and Environmental Dermatology, University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria.
http://www.photobiology.com/photobiology99/contrib/knobler/index.htm

==

The intravenous laser blood irradiation - Introduction of a New Therapy. M. H. Weber, Th. Fußgänger-May, T. Wolf
http://www.webermedical.com/downloads/02.pdf

==

 "The first experience of Photodithazine clinical application for photodynamic therapy of malignant tumors."
E.Ph. Stranadko1, G.V.Ponomarev2, V.M.Mechkov4, M.V.RiaboV, A.V.Ivanov3, A.V.Reshetnikov2, U.M-Koraboyev1
http://veta-grand.narod.ru/publ/publ003.html

==

"Effect of intravenous laser blood irradiation on endothelial dysfunction in patients with hypertensive disease." Klin Med (Mosk). 2009;87(6):22-5. http://www.ncbi.nlm.nih.gov/pubmed/19670711

==

Health1clinic has 129 relevant articles but they do not have links so you will have to type in the titles seperately:
http://www.health1clinic.com/published-studies/bibliography

Bibliographies complied from available literature in the field of BioPhotonic Therapy

Most of these are published medical studies in the field of UV light therapy. There are a lot of studies that have not been translated or are not available to us here in the States.

Over 70 Years of History
Over 140 Published Medical Studies  (129 in this list)
Over 1 Million Patients
No Side Effects (Almost)
Over 3,000 Practitioners (mostly in Europe)
 

==

Photodynamic Therapy For Cancer?
http://www.science20.com/news_articles/photodynamic_therapy_cancer-76090

"In a new study, Dr Tuomas Tammela and colleagues at the University of Helsinki, Finland, investigated whether eradicating tumor-associated lymphatic vessels and the tumor cells they contain using photodynamic therapy (PDT) with a light-activated cytotoxic drug could reduce or eliminate tumor metastasis."

 Here is the scientific reference to the study:
 
  Photodynamic Ablation of Lymphatic Vessels and Intralymphatic Cancer   Cells Prevents Metastasis.
  http://stm.sciencemag.org/content/3/69/69ra11.abstract

==

From Cancer.org
 
Ultraviolet blood irradiation treatment is approved by the U.S. Food and Drug Administration (FDA) for treating T-cell lymphoma involving the skin. Photopheresis is sometimes used conventionally when organ transplant rejection or graft-versus-host disease (a complication related to bone marrow or stem cell transplants) does not respond to usual conventional treatments. Some clinical trial results look promising for the treatment of immune system diseases such as multiple sclerosis, systemic sclerosis, rheumatoid arthritis, lupus, and type 1 diabetes. Available scientific evidence does not support claims for alternative uses of UV blood irradiation.
http://www.cancer.org/Treatment/TreatmentsandSideEffects/ComplementaryandAlternativeMedicine/ManualHealingandPhysicalTouch/light-therapy

==

Photodynamic Therapy - Wikipedia
http://en.wikipedia.org/wiki/Photodynamic_therapy

 ( * See Advantages and Limitations * ) ( ** Also link to the numerous references at the bottom ** )

==

Ultraviolet Blood Irradiation Therapy (Photo-Oxidation) - The Cure That Time Forgot
Robert Jay Rowen, MD
http://www.doctorrowen.com/docs/ubi.pdf

==


 This is a very interesting field of study and I hope the references I have compiled provide you with good array of information about this topic!

umiat

 
 

Sun 29 Jan 2012 - 11:41 am UTC

Accepted and rated

disquisitive
Customer

A comprehensive compilation of ultraviolet blood irradiation therapy references and other oxidative therapies. The knowledge found drilling down your links' references provides quite a well of information. Thank you very much umiat.

 

Sun 29 Jan 2012 - 11:59 am UTC

Comment

disquisitive
Customer

myoarin - Your post "There are quite a few hits found by googling with:   UV Blutbestrahlung" was also excellent. I also appreciate the link to: http://www.uvblutbestrahlung.de/ . After some glitches in translation using Yahoo Babel Fish I was able to get to some very interesting reading about Haematogene oxidation therapy (HOT). Danke

 

Sun 29 Jan 2012 - 12:33 pm UTC

Comment

myoarin
User

Disquisitive,

My pleasure to help.  I find it interesting that some sites seem full of the value of UV blood irradiation, whereas the Germans found it useless, and one site mentioned that in Russia until the 1980s it was an accepted medical practice.  But then?  Why not?

Myo

 

Sun 29 Jan 2012 - 1:14 pm UTC

Uclue Researcher Answer clarification

JD Umiat
Researcher

Thank you very much, disquisitive, for your kind rating and tip!

 

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