19 May 2007 04:13 UTCSat 19 May 2007 - 4:13 am UTC
To what extent would beta Thalassemia (minor/intermedia) effect blood alcohol levels?
20 May 2007 07:34 UTCSun 20 May 2007 - 7:34 am UTC
Since there's been no response to your question for awhile, I thought I'd let you know that my searches didn't reveal any specific relationship between Thalassemia and blood alcohol levels.
What I did find were indications that those with this condition should avoid excessive use of alcohol in order to preclude weakening the immune system and thereby promoting infection and/or fever.
20 May 2007 16:10 UTCSun 20 May 2007 - 4:10 pm UTC
PubMed posts an article that refers to a patient with thalassemia minor who ingested 80 g of alcohol a day who presented with an overlod of iron with deposits and a hepatic iron ration compatible with primary hemochromatosis. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1762461&dopt=Abstract
Med Clin (Barc). 1991 Nov 16;97(17):660-2.
[Thalassemia minor with iron overload: genetic and clinical study of a family]
[Article in Spanish]
Queipo de Llano MP, Yebra M, Moreno M, Lacoma F, Gea JC, Berrocal E.
Servicio de Hematologia, Clinica Puerta de Hierro, Universidad Autonoma, Madrid.
"A patient with thalassemia minor (TM) is reported who ingested 80 g of alcohol/day and presented an important overload of iron with deposits and a hepatic iron ratio compatible with primary hemochromatosis. The results obtained from the study of histocompatibility antigens, clinical manifestations and family analysis discarded the possibility of two genetic diseases, beta-thalassemia and primary hemochromatosis, being concomitantly present in the same progeny. Thalassemia minor and alcoholic hepatopathy are considered as having acted together and being responsible for the iron overload. The relation between alcohol ingested, TM and iron deposits is discussed."
Let me know if this information is satisfactory for your needs.
22 May 2007 12:04 UTCTue 22 May 2007 - 12:04 pm UTC
It appears that your speculation is very much on the right track.
I did not come across any information on the web, or in legal databases, that specifically discusses Thalassemia and blood alcohol levels,
However, Thalassemia leads to anemia, and there is certainly information on anemia in the context of blood alcohol levels. In particular, anemia alters the typical hematoocrit readings, which in turn, can throw off some measures of blood alcohol.
Here are some links on this topic:
The Effect of Anemia on Breath Tests
...A person suffering from anemia has a low red blood cell count, perhaps half as much as would be normal. Put simply, when there are fewer red blood cells, the body will increase the amount of plasma to fill the void....It follows that the higher the ratio of liquid to solids in the blood (called the hematocrit), the higher the amount of alcohol in the blood — and the higher will be the reading on the breathalyzer. ...In other words, a person with a true BAC of .09% but a hematocrit of 54% would test on an otherwise “accurate” machine as .11%. Just because he/she is anemic — or simply varies from the statistical norm.
...Yet another potential source of error in breath-alcohol analysis involves the variability in the composition of the blood.
I trust this information provides just the sort of resources you were looking for regarding a connection between Thalassemia and blood alcohol levels.
However, if there's anything more I can do for you on this, just let me know by posting a Clarification request, and I'm at your service.
All the best,
22 May 2007 16:14 UTCTue 22 May 2007 - 4:14 pm UTC
I don't want to leave you hanging on this, so please let me know if there's anything more I can do for you.
I checked the internet, as well as Lexis-Nexis legal sources, for information directly relating to Thalassemia, but there simply doesn't appear to be anything regarding blood alcohol content.
However, if the more general info on anemia seems off the mark to you, I'll be glad to keep digging. Just let me know why the links I provided give you pause, and I'll see if there is any alternative information out there.
Thanks for your kind remarks about Uclue. We're pretty excited, too.