Question: Serine Protease testing

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adjclarks21 

Customer

 15 Jan 2016 16:17 UTCFri 15 Jan 2016 - 4:17 pm UTC 

Hello. 

I am looking for a company that that test for Serine Protease activity.  We have a oil we need tested.  We are not interested in a kit to do the testing ourselves, we need a company that will test it for us. 

Need company name, website and phone number.

Thank you.

 

JD Umiat 

Researcher

 15 Jan 2016 17:02 UTCFri 15 Jan 2016 - 5:02 pm UTC 

I am not well-versed in this type of testing. Is this what you need?

BioReliance
http://www.bioreliance.com/us/services/biopharmaceutical-services/raw-material-testing/endotoxin-testing-%28lal%29

Toll Free
1.800.756.5658
US - Local 1.301.738.1000
Email
info@bioreliance.com


The USP chromogenic method is based on the activation of a serine protease (coagulase) by the endotoxin, which is the rate-limiting step of the clotting cascade. The assay measures the activation of the serine protease as opposed to the end result of this activation, which is clotting. The natural substrate, coagulogen, is replaced by a chromogenic substrate. On cleavage of this substrate a chromophore is released from the chromogenic peptide and is measured by spectrophotometry.

The USP chromogenic method is quantitative and can provide a greater sensitivity over a wider range. The sensitivity of this assay is 0.10 EU/ml.

BioReliance CRO is an expert in both types of endotoxin tests and can provide you with advice on the best assay for your drug study or lot release needs.

 

adjclarks21 

Customer

 15 Jan 2016 17:13 UTCFri 15 Jan 2016 - 5:13 pm UTC 

No.  That is not it.  I just spoke with them and they do not do Serine Protease testing.

 

Bobbie Sevens 

Researcher

 15 Jan 2016 17:29 UTCFri 15 Jan 2016 - 5:29 pm UTC 

Hi

Please let me know if this is the correct test.

Serine Protease 3 Antibody
http://ltd.aruplab.com/Tests/Pub/0050527

Contact information

Client Services - (800) 522-2787

email: clientservices@aruplab.com

ARUP Laboratories
500 Chipeta Way
Salt Lake City, UT 84108-1221

Source:

ARUP's Laboratory Test Directory

ARUP's Laboratory Test Directory contains complete, up-to-date test information, including methodology and reporting times, collection and transportation specifications, reference intervals, test notes, and CPT codes. Clients can access entries via an A to Z index and search by test name, key word, test number, or mnemonic.
http://www.aruplab.com/testing

 

adjclarks21 

Customer

 15 Jan 2016 18:10 UTCFri 15 Jan 2016 - 6:10 pm UTC 

No, I ran this by Dr. Crutchfield and this won't work either because they are just testing for an antibody. 

Please keep trying! I'm at my wits end!!

 

JD Umiat 

Researcher

 15 Jan 2016 18:43 UTCFri 15 Jan 2016 - 6:43 pm UTC 

Are you looking to submit a cosmetic oil product to test for levels of serine protease? Is this company a possibility?


UL
http://industries.ul.com/personal-care-and-beauty?gclid=CPffp5y7rMoCFROTfgodCSgNFg

Analytical testing:
http://services.ul.com/service/analytical-testing/?ind=Personal+Care+and+Beauty

 

JD Umiat 

Researcher

 15 Jan 2016 18:46 UTCFri 15 Jan 2016 - 6:46 pm UTC 

 

adjclarks21 

Customer

 15 Jan 2016 20:13 UTCFri 15 Jan 2016 - 8:13 pm UTC 

Hi.  Not ignoring you, just waiting on a response from UL.  Avomeen said they didn't.

Thanks again! Please don't give up!

 

David Sarokin 

Researcher

 16 Jan 2016 20:59 UTCSat 16 Jan 2016 - 8:59 pm UTC 

From what I see, serine proteases are a category that include numerous discrete substances:

http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Serine_Proteases.html
Serine Proteases


Is it possible that a test for a specific substance will meet your needs (several such lab tests exist) rather than a test for overall SP levels?

 

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